Advances in polycyclization cascades in natural product synthesis
نویسندگان
چکیده
Cascade reactions are among the most powerful means to achieve construction of multiple ring systems in a single step. This tutorial review describes recent advances use polycyclization cascades natural product synthesis.
منابع مشابه
Recent advances in natural product discovery.
Natural products have been and continue to be the source and inspiration for a substantial fraction of human therapeutics. Although the pharmaceutical industry has largely turned its back on natural product discovery efforts, such efforts continue to flourish in academia with promising results. Natural products have traditionally been identified from a top-down perspective, but more recently ge...
متن کامل“ Metathesis in Natural Product Synthesis ”
Institute of Organic Chemistry, Romanian Academy, 202B Spl. Independentei, PO Box 35-108, 060023 Bucharest, Romania; E-mail: *[email protected]; **[email protected] “Metathesis in Natural Product Synthesis” subtitled ‘Strategies, Substrates and Catalysts’ benefits from a foreword by Robert H. Grubbs, joint recipient of the 2005 Nobel Prize in Chemistry for his work on the development of the...
متن کاملNatural Product Synthesis
The Lycopodium alkaloids are a family of structurally complex natural products, which have provoked long-term interests in their total syntheses because of their unique and fascinating architectures and potential biological activities. In particular, fawcettimine-type Lycopodium alkaloids, such as fawcettimine (1) and fawcettidine (2) (Scheme 1), have attracted broad attention from the syntheti...
متن کاملRecent Advances in Substrate-Controlled Asymmetric Cyclization for Natural Product Synthesis.
Asymmetric synthesis of naturally occurring diverse ring systems is an ongoing and challenging research topic. A large variety of remarkable reactions utilizing chiral substrates, auxiliaries, reagents, and catalysts have been intensively investigated. This review specifically describes recent advances in successful asymmetric cyclization reactions to generate cyclic architectures of various na...
متن کاملAdvances in solution- and solid-phase synthesis toward the generation of natural product-like libraries.
4.1. Aeruginosin 298-A 2002 4.2. Bleomycin 2003 4.3. Clavulones 2004 4.4. Curacin A 2005 4.5. Dysidiolide 2006 4.6. Epothilone 2006 4.7. Erythromycin A 2007 4.8. Estrone 2008 4.9. Fellutamide 2009 4.10. Fumiquinazoline 2010 4.11. Gougerotin 2010 4.12. Homocamptothecin 2010 4.13. Illudin 2011 4.14. Macrosphelide 2012 4.15. Mappicine 2012 4.16. Mniopetals and Marasmanes 2013 4.17. Murisolin 2014 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2021
ISSN: ['0306-0012', '1460-4744']
DOI: https://doi.org/10.1039/d0cs00768d